Fight Cancer with Natural Angiogenesis Inhibitors

Cancerous tumors cannot survive if they have no supply of nutrients delivered to them through the blood stream. Cancerous tumors tell the body to create new blood vessels that feed into the tumors in order to get this supply of nutrients. This is called angiogenesis. Slow or stop this process and cancer may be slowed, halted, or even reversed.

Many natural supplements have demonstrated anti-angiogenesis activity in vitro, in animals, or occasionally in vivo or through anecdote. Most all of them have also demonstrated a lack of significant toxicity. They typically block new vessel formation in multiple ways, providing advantages over synthetic drugs which work by a single mechanism only. In addition, many such supplements simultaneously have other anti-cancer properties as well.

If something is definitely safe as well as possibly effective, then that qualifies it for entry into an arsenal of natural cancer options.

Since angiogenesis is an essential process for healing injuries, there is theoretical risk of increasing chance of ulceration and bleeding while taking angiogenesis inhibitors. This has been shown in at least one synthetic drug. However, a great many of these supplements are taken regularly by many people for reasons not having anything to do with cancer, and are considered safe in general. So this risk may be negligible in many natural products, though no studies have thoroughly examined this.

Tumors often create disorganized and leaky vessels that cause local bleeding and edema. Stopping angiogenesis can also stop this unwanted effect of cancer.

Real cancer treatment needs an integrative approach that attacks cancer from all sides. Inhibiting angiogenesis is one of those sides. Here is a list of natural products in alphabetical order that all have demonstrated at least some potential for inhibiting angiogenesis. Some products with these ingredients can be very helpful, and some can be a total waste:

List on Potential Natural Angiogenesis Inhibitors
Aloe barbadensis (aloe vera leaf and pulp extracts)
Angelica sinensis (aqueous extracts)
Antioxidants (vitamins A, C, E; Se, Zn; carotenoids, flavonoids, coenzyme Q10, N-acetylcysteine, lipoic acid)
Artemisia annua (artemisinin, artesunate)
Berberis paraspecta Root
Bilberry
Bindweed
Boswellia
Bovine cartilage
Bromelain
Camellia sinensis (epigallocatechin)
Caryophylli flos
Catharanthus roseus Leaf
Chinese skullcap
Chrysobalanus icaco (methanol extract)
Cinnamomi cortex
Coptis chinensis Rhizome
Curcuma longa (curcumin)
Dysoxylum binectariferum (flavopiridol)
Epigallocatechin-3 gallate/green tea
Flos magnoliae (magnosalin)
Foeniculi fructus
Ganoderma lucidum (triterpenoids)
Garlic
Ginkgo biloba (ginkgolide B)
Glycyrrhiza glabra (isoliquiritigenin,; glabridin)
Green-lipped mussel
Heparin (prescription)
Hibiscus sabdariffa L. (protocatechuic acid)
Liquorice
Livistona chinensis (aqueous extract from seed)
Matricaria chamomilla (flavonoids: apigenin, fisetin)
Ocimum sanctum (carnosol, ursolic acid)
Omega-3 fatty acids (eicosapentaenoic acid, docosahexaenoic acid)
Magnolia obovata (honokiol, seed cones)
Panax ginseng (saponins: 20(R)- and 20(S)-ginsenoside-Rg3)
Polypodium leucotomos (difur)
Poria cocos (1–3-a-D-glucan)
Polygonum cuspidatum (resveratrol)
Proanthocyanidin
Quercetin
Rabdosia rubescens Hora (ponicidin and oridonin)
Rosmarinus officinalis (carnosol and ursolic acid)
Scrophularia ningpoensis Root
Scutellaria baicalensis (baicalin and baicalein, Chinese skullcap)
Selenium
Shark cartilage (water soluble extract AE-941)
Silybum marianum (silymarin / milk thistle)
Soy isoflavones (genistein, daidzein)
Squalus acanthias (dogfish liver: squalamine)
Tanacetum parthenium L. (parthenolide)
Tabebuia avellanedae (b-lapachone)
Taxus brevifolia (taxoids)
Taxus chinensis Bark
Viscum album (lectins, European Mistletoe)
Vitamin D (1a,25-D3)
Zedoariae rhizome
Zingiber officinale (6-gingerol)

Update: A few more…

Noni
Sea cucumber
Lactoferrin
Zinc

More info:
Natural health products that inhibit angiogenesis: a potential source for investigational new
agents to treat cancer—Part 1 S.M. Sagar MD,* D. Yance MH,† and R.K. Wong MD Link

Natural health products that inhibit angiogenesis: a potential source for investigational new
agents to treat cancer—Part 2 S.M. Sagar MD,* D. Yance MH,† and R.K. Wong MD Link

Disclaimer: This article does not contain any medical advice. This article contains opinion and is for informational purposes only. If seeking medical advice, consult a licensed physician.

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